Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp Isolated from an Antarctic Marine Sediment
- 주제(키워드) Streptomyces sp. , cold water natural product , marine natural product , zizaane-type sesquiterpenoid
- 주제(기타) Chemistry, Medicinal
- 설명문(일반) [Kim, Dayoung; Lee, Jihye; Leutou, Alain S.; Choi, Bomi; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Lee, Eun Ju; Hwang, Ji Sun; Chin, Jungwook; Cho, Sung Jin; Hwang, Hayoung] DGMIF, New Drug Dev Ctr, Daegu 41061, South Korea; [Shin, Yern-Hyerk; Oh, Dong-Chan] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, San 56-1, Seoul 08826, South Korea; [Hahn, Dongyup] Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; [Hahn, Dongyup] Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; [Choi, Hyukjae] Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongsangbukdo, South Korea; [Hong, Yong Deog; Ko, Jaeyoung] Mat Lab Amorepacific R&D Unit, Yongin 17074, Gyeonggi Do, South Korea; [Seong, Chi Nam] Sunchon Natl Univ, Coll Life Sci & Nat Resource, Dept Biol, Sunchon 57922, South Korea; [Maloney, Katherine N.] Point Loma Nazarene Univ, Dept Chem, 3900 Lomaland Dr, San Diego, CA 92106 USA; [Yang, Inho] Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151784
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/md16040130
초록/요약
Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.
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