Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis
- 주제(기타) Biotechnology & Applied Microbiology; Immunology; Microbiology; Pharmacology & Pharmacy
- 설명문(일반) [Leutou, Alain S.; Yang, Inho; Le, Tu Cam; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nanosci, Seoul, South Korea; [Hahn, Dongyup] Kyungpook Natl Univ, Sch Food & Biotechnol, Daegu, South Korea; [Hahn, Dongyup] Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea; [Lim, Kyung-Min] Ewha Womans Univ, Coll Pharm, Seoul, South Korea; [Fenical, William] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA
- 등재 SCIE, SCOPUS
- 발행기관 JAPAN ANTIBIOTICS RESEARCH ASSOC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151785
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41429-018-0033-3
초록/요약
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
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