Spectroscopic methods to analyze drug metabolites
- 주제(키워드) Spectroscopy , Drug metabolites , Mass spectrometry , Nuclear magnetic resonance , Ultraviolet-visible spectroscopy , Infrared spectroscopy , Circular dichroism , Raman spectroscopy , Surface plasmon resonance
- 주제(기타) Chemistry, Medicinal; Pharmacology & Pharmacy
- 설명문(일반) [Yi, Jong-Jae; Son, Woo Sung] CHA Univ, Dept Pharm, Coll Pharm, 120 Haeryong Ro, Pocheon Si 11160, Gyeonggi Do, South Korea; [Park, Kyeongsoon] Chung Ang Univ, Dept Syst Biotechnol, Coll Biotechnol & Nat Resources, 4726 Seodong Daero, Anseong 17546, Gyeonggi Do, South Korea; [Kim, Won-Je] Seoul Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, 1 Gwanak Ro, Seoul 08826, South Korea; [Rhee, Jin-Kyu] Ewha Womans Univ, Dept Food Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 PHARMACEUTICAL SOC KOREA
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151813
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-018-1010-x
초록/요약
Drug metabolites have been monitored with various types of newly developed techniques and/or combination of common analytical methods, which could provide a great deal of information on metabolite profiling. Because it is not easy to analyze whole drug metabolites qualitatively and quantitatively, a single solution of analytical techniques is combined in a multilateral manner to cover the widest range of drug metabolites. Mass-based spectroscopic analysis of drug metabolites has been expanded with the help of other parameter-based methods. The current development of metabolism studies through contemporary pharmaceutical research are reviewed with an overview on conventionally used spectroscopic methods. Several technical approaches for conducting drug metabolic profiling through spectroscopic methods are discussed in depth.
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