Hypervalent Iodine-Mediated Alkene Functionalization: Oxazoline and Thiazoline Synthesis via Inter-/Intramolecular Aminohydroxylation and Thioamination
- 주제(키워드) hypervalent iodine , metal-free , oxazoline , thiazoline , aminohydroxylation , thioamination
- 주제(기타) Chemistry, Applied; Chemistry, Organic
- 설명문(일반) [Jeon, Hyeonho; Kim, Darong; Lee, Ji Hoon; Song, Jaeyoung; Lee, Won Seok; Hong, Ki Bum] DGMIF, NDDC, 80 Cheombok Ro, Daegu, South Korea; [Lee, Seok Beom; Choi, Sungwook] Chungnam Natl Univ, Dept New Drug Discovery & Dev, Daejon, South Korea; [Kang, Soosung] Ewha Womans Univ, Coll Pharm, Seoul, South Korea; [Kang, Soosung] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul, South Korea; [Jeon, Hyeonho; Kang, Dong Wook] Catholic Univ Daegu, Dept Pharmaceut Sci & Technol, Gyongsan 38430, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151833
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/adsc.201701087
초록/요약
A metal-free oxidative difunctionalization of N-allylamides and N-allylthioamides has been developed. This system features the use of a hypervalent iodine oxidant with electron-deficient amines to access 5-amino-oxazoline and thiazoline scaffolds under mild conditions. Notably, various electron-deficient amines were systematically evaluated and we verified the reaction profile was originated from an attached (benzene)sulfonyl group.
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