Chest wall recurrence in pT1-2N0-1 breast cancer patients after mastectomy without radiotherapy
- 주제(키워드) Breast cancer , Post-mastectomy radiation therapy , Chest wall recurrence risk factor , Chest wall irradiation , 1-3 positive nodes
- 주제(기타) Oncology
- 설명문(일반) [Chang, Ji Hyun; Kim, Suzy] Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Radiat Oncol, Seoul, South Korea; [Shin, Kyung Hwan; Chie, Eui Kyu; Kim, Jin Ho] Seoul Natl Univ, Coll Med, Dept Radiat Oncol, Seoul 03080, South Korea; [Ahn, Seung Do; Kim, Su Ssan] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiat Oncol, 88 Olymp Ro,43 Gil, Seoul 138736, South Korea; [Park, Hae Jin] Hanyang Univ Hosp, Dept Radiat Oncol, Seoul, South Korea; [Kim, Yong Bae] Yonsei Univ, Coll Med, Dept Radiat Oncol, Seoul, South Korea; [Park, Won] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiat Oncol, Seoul, South Korea; [Kim, Yeon-Joo] Natl Canc Ctr, Proton Therapy Ctr, Dept Radiat Oncol, Goyang, South Korea; [Shin, Hyun Soo] CHA Univ, Sch Med, Dept Radiat Oncol, Pochon, South Korea; [Kim, Jin Hee] Keimyung Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; [Lee, Sun Young] Chonbuk Natl Univ Hosp, Dept Radiat Oncol, Jeonju, South Korea; [Kim, Kyubo] Ewha Womans Univ, Sch Med, Dept Radiat Oncol, Seoul, South Korea; [Park, Kyung Ran] Ewha Womans Univ, Mokdong Hosp, Dept Radiat Oncol, Seoul, South Korea; [Jeong, Bae Kwon] Gyeongsang Natl Univ, Sch Med, Dept Radiat Oncol, Jinju, South Korea; [Kim, Ja Young] Asan Med Ctr, Dept Radiat Oncol, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151856
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10549-018-4707-0
초록/요약
Purpose In correlation with the nodal status in the era of modern radiotherapy, the chest wall recurrence (CWR) rate was investigated in pT1-2N0-1 breast cancer patients after a mastectomy without post-mastectomy radiotherapy (PMRT). Methods The data from the patients participating in two South Korean multi-institutional studies (KROG 14-22; N = 1842 and KROG 14-23; N = 1382) were analyzed. In total, 3224 pT1-2N0-1 breast cancer patients who underwent mastectomy without PMRT were analyzed. Results The median follow-up time was 72.2 months (range 0.8-125.2 months). The overall CWRs during the follow-up period were 1.68% in N0 patients and 2.82% in N1 patients. There was no statistically significant difference in 5-year and 10-year CWR-free survival (CWRFS) between the N0 and N1 patients. Of the 70 patients with CWR, 33 (1% of all the patients) had isolated CWR, and the 10-year overall survival rate in this group was 96.9%. After the propensity score matching of the N0 and N1 groups, there was still no difference in CWRFS by nodal status. Conclusions The incidence of CWR in pT1-2N0-1 breast cancer patients is very low, especially with isolated recurrence. Also, the obtained data showed that the nodal status had no impact on CWRFS.
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