Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery
- 주제(키워드) Metabolic engineering , Microbial cell factory , Corynebacterium glutamicum , Plasmid vectors , Promoters , Bio-based chemicals
- 주제(기타) Biotechnology & Applied Microbiology
- 설명문(일반) [Baritugo, Kei-Anne; David, Yokimiko; Park, Si Jae] Ewha Womans Univ, Div Chem Engn & Mat Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea; [Kim, Hee Taek; Joo, Jeong Chan] Korea Res Inst Chem Technol, Div Convergence Chem, Ctr Biobased Chem, POB 107,141 Gajeong Ro, Daejeon 34602, South Korea; [Choi, Jong-il] Chonnam Natl Univ, Dept Biotechnol & Bioengn, Gwangju 61186, South Korea; [Hong, Soon Ho] Univ Ulsan, Dept Chem Engn, Ulsan 44610, South Korea; [Jeong, Ki Jun] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Plus Program BK21, Daejeon 34141, South Korea; [Choi, Jong Hyun] KRIBB, Jeonbuk Branch Inst, Microbial Biotechnol Res Ctr, 181 Ipsin Gil, Jeongeup 56212, Jeonbuk, South Korea
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151894
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s00253-018-8896-6
초록/요약
Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2-C6 platform chemicals using recombinant C. glutamicum.
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