A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite
- 주제(키워드) ESIPT , Hypochlorite , Living cells , Tissue imaging , Two-photon
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ltd
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151969
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.dyepig.2018.01.027
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Hypochlorous acid (HOCl) is one important member of reactive oxygen species (ROS) familyresponsible for various human diseases. Although many contributions have been made to develop fluorescent probes for sensing HOCl, many of them suffer small Stokes shifts, sophisticated synthetic procedure, and slow reaction rate. In the current study, we designed and synthesized an ESIPT based fluorescence probe with diaminomeleonitrile (DMN) as reactive site. The probe can detect HOCl with high selectivity and sensitivity. It also has large Stokes shift and rapid reaction rate. Moreover, it can be utilized to monitor exogenous and endogenous HOCl in living cells and tissues via two-photon microscopy. © 2018 Elsevier Ltd
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