Design and applications of fluorescent detectors for peroxynitrite
- 주제(키워드) Boronic acids or boronates , Fluorescence probes , In vivo imaging , Intracellular imaging , N-dearylation , Peroxynitrite , Reactive oxygen species (ROS)
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier B.V.
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151971
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.ccr.2018.06.013
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Peroxynitrite (ONOO−) is one of the endogenous reactive oxygen species (ROS), which causes damage to a wide array of molecular components in the cells, including DNA and proteins, owing to its high oxidizing as well as nitrating properties. However, the precise pathogenic roles played by this substance in biological systems have not yet been elucidated completely owing to its short lifetime, high reactivity, low concentration and elusive nature in the in vivo applications. Thus, the development of more sensitive and selective techniques for detecting ONOO−, with high biocompatibilities, sensitivities, and site-specificities, is a significant goal. This review summarizes the recent advances that have been made in developing fluorescent sensors for ONOO− and their biological applications in diverse living systems. © 2018 Elsevier B.V.
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