Supplementation of a polyphenol extract from Ecklonia cava reduces body fat, oxidative and inflammatory stress in overweight healthy subjects with abdominal obesity: A randomized, placebo-controlled, double-blind trial
- 주제(키워드) Ecklonia cava extract , Inflammatory stress , Obesity , Oxidative stress , Polyphenol
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier Ltd
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000151982
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.jff.2018.04.062
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
A randomized, placebo-controlled, double-blind trial was conducted using subjects with a body mass index over 25 kg/m2 and under 30 kg/m2. Eighty subjects were randomly assigned to receive either a placebo or Ecklonia cava extract (Seapolynol, 360 mg/day) for 12 weeks. In response to Seapolynol consumption, the body fat was significantly reduced from the baseline value. In the abdominal obesity subgroup, Seapolynol group presented with a significant decrease in total adipose tissue area, percent body fat and fat/lean mass ratio and an increase in skeletal muscle index. The oxidized low-density lipoprotein levels and endogenous antioxidant enzyme activities were significantly affected by Seapolynol supplementation. In addition, Seapolynol supplementation significantly increased the mRNA expression of lipid oxidation-related genes and decreased the expression of lipid synthesis-related genes. Inflammatory markers were also reduced by Seapolynol supplementation. In conclusion, Seapolynol may exert beneficial effects on obesity and related metabolic disorders in overweight and obese individuals. © 2018 Elsevier Ltd
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