Weight change and risk of uterine leiomyomas: Korea Nurses' Health Study
- 주제(키워드) Body mass index , weight change , body size , uterine leiomyoma , Korea nurses' health study
- 주제(기타) Medicine, General & Internal; Medicine, Research & Experimental
- 설명문(일반) [Lee, Ji-Eun] Sookmyung Womens Univ, Dept Food & Nutr, Seoul, South Korea; [Song, Sihan; Lee, Jung Eun] Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, 1 Gwanak Ro, Seoul 08826, South Korea; [Cho, Eunyoung] Brown Univ, Warren Alpert Med Sch, Dept Dermatol, Providence, RI 02912 USA; [Cho, Eunyoung] Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA; [Cho, Eunyoung] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; [Cho, Eunyoung] Harvard Med Sch, Boston, MA USA; [Jang, Hee Jung] Hallym Univ, Div Nursing, Chunchon, South Korea; [Jang, Hee Jung] Hallym Univ, Res Inst Nursing Sci, Chunchon, South Korea; [Jung, Heeja] Konyang Univ, Coll Nursing, Daejeon, South Korea; [Lee, Hea-Young] Doowon Tech Univ, Dept Nursing, Anseong, South Korea; [Kim, Sue] Yonsei Univ, Coll Nursing, Seoul, South Korea; [Lee, Hea-Young] Ewha Res Inst Nursing Sci, Seoul, South Korea; [Kim, Oksoo] Ewha Womans Univ, Coll Nursing, Seoul, South Korea; [Lee, Jung Eun] Seoul Natl Univ, Res Inst Human Ecol, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 TAYLOR & FRANCIS LTD
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155809
- 본문언어 영어
- Published As http://dx.doi.org/10.1080/03007995.2018.1462783
초록/요약
Objective: This study examined the associations between anthropometric measures and uterine leiomyomas. Methods: This study included a total of 5,062 women (median age of 35.5 years) who had experienced pregnancy and, of these women, 210 reported a diagnosis of uterine leiomyomas within the past 2 years prior to baseline in the Korea Nurses' Health Study. Participants were asked about their anthropometric factors. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression models. Results: Mean body mass index (BMI) was 21.8 kg/m(2) among non-cases. An increase in weight from the age of 18 years to the present was associated with increased risk of uterine leiomyomas (p for trend = .002); compared to women whose weight remained stable, the multivariate ORs (95% CIs) were 1.84 (1.22-2.76) for weight gain of 5-10 kg and 2.00 (1.25-3.20) for weight gain of more than 10 kg since age 18. A similar pattern was observed when the analysis was limited to women with a BMI of 18.5-25 kg/m(2). Current weight was associated with higher odds of uterine leiomyomas. No associations were found for body size in childhood or in adolescence, weight at age 18, current BMI, or current body size. Conclusions: Weight gain in adulthood was associated with increased risk of uterine leiomyomas in Korean women, even in those with normal weight.
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