Long-term effects of the SLC2A9 G844A and SLC22A12 C246T variants on serum uric acid concentrations in children
- 주제(키워드) Children , Longitudinal study , Urate transporter 1 , Uric acid
- 주제(기타) Pediatrics
- 설명문(일반) [Lee, Hye Ah; Park, Bo Hyun; Park, Hyesook] Ewha Womans Univ, Coll Med, Dept Prevent Med, 1071 Anyangcheon Ro, Seoul 158710, South Korea; [Lee, Hye Ah] Ewha Womans Univ, Mokdong Hosp, Clin Trial Ctr, Seoul, South Korea; [Park, Eun Ae; Cho, Su Jin; Kim, Hae Soon] Ewha Womans Univ, Coll Med, Dept Pediat, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 BMC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155818
- 본문언어 영어
- Published As http://dx.doi.org/10.1186/s12887-018-1272-y
초록/요약
Background: We evaluated the effects of two single-nucleotide polymorphisms on UA concentrations in the first decade of life using repeated-measures data. Methods: We included all subjects who were followed-up at least once and for whom we had both UA and genotypic data (i.e., 375, 204, 307, and 363 patients aged 3, 5, 7, and 9 years, respectively). All participated in the Ewha Birth and Growth Cohort study. We used a mixed model analysis to estimate the longitudinal association of serum UA concentration due to the rs3825017 (SLC22A12 c. 246C > T) and rs16890979 (SLC2A9 c. 844G > A) genotypes. Results: Overall, the tracking coefficient of UA concentrations in children 3 to 9 years of age was 0.31, and was higher in boys than in girls (0.34 vs. 0.29, respectively). Regarding individual variance, serum UA concentrations decreased as age increased (beta = -0.07, p < 0.05), but there were no significant differences by sex. The effects of rs3825017 on UA concentration were significant in boys, but not in girls. Boys with the T allele of rs3825017 had higher concentrations than their counterparts regardless of the time of follow-up. The rs16890979 genotypes were not significantly associated with serum UA concentration in either sex. Conclusion: This study showed that rs3825017 in the SLC22A12 gene was associated with UA concentration in childhood.
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