Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression
- 주제(키워드) CART peptide , Addiction , Psychostimulant , Depression
- 주제(기타) Biochemistry & Molecular Biology; Pharmacology & Pharmacy
- 설명문(일반) [Meng, Qing] Nanchang Univ, Queen Mary Inst, Sch Med, Nanchang 33006, Jiangxi, Peoples R China; [Kim, Hyoung-Chun] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon 24341, South Korea; [Oh, Seikwan] Ewha Womans Univ, Sch Med, Dept Mol Med, Seoul 07985, South Korea; [Oh, Seikwan] Ewha Womans Univ, Sch Med, TIDRC, Seoul 07985, South Korea; [Lee, Yong-Moon; Oh, Ki-Wan] Chungbuk Natl Univ, Dept Pharm, Coll Pharm, Osong 28160, South Korea; [Hu, Zhenzhen] Nanchang Univ, Dept Pathophysiol, Coll Med, Nanchang 33006, Jiangxi, Peoples R China
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC APPLIED PHARMACOLOGY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155849
- 본문언어 영어
- Published As http://dx.doi.org/10.4062/biomolther.2018.141
초록/요약
Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca2+/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and gamma-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an antidepressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimulant-induced depression.
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