Two new naphthalenic lactone glycosides from Cassia obtusifolia L. seeds
- 주제(키워드) Advanced glycation end-products , Cassia obtusifolia , Naphthalenic lactone glycosides
- 후원정보 Ministry of Science, ICT and Future Planning
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 Pharmaceutical Society of Korea
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155898
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-018-1044-0
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Two new naphthalenic lactone glycosides, (3S)-9,10-dihydroxy-7-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-benzo[g]isochromene-3-carboxylic acid 9-O-β-d-glucopyranoside (1) and (3R)-cassialactone 9-O-β-d-glucopyranoside (2) were isolated from seeds of Cassia obtusifolia Linn., along with five known compounds: (3R)-cassialactone 9-O-β-d-gentiobioside (3), emodin 1-O-β-gentiobioside (4), 1-hydroxyl-2-acetyl-3,8-dimethoxy-naphthalene 6-O-β-d-apiofuranosyl-(1 → 2)-β-d-glucopyranoside (5), rubrofusarin 6-O-β-d-gentiobioside (6), rubrofusarin 6-O-β-d-triglucoside (7). Structures of 1 and 2 were elucidated by NMR and HR-ESI-MS spectroscopic analysis. Their stereochemistry was determined by CD experiment. All compounds were tested for their ability to inhibit the formation of advanced glycation end-products in vitro. Compounds 1, 2, 3, 5, and 6 showed significant in vitro inhibitory activities (IC50 values of 11.63, 23.40, 7.32, 89.03, and 38.89 µM, respectively). © 2018, The Pharmaceutical Society of Korea.
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