Mesenchymal stem cell-driven activatable photosensitizers for precision photodynamic oncotherapy
- 주제(키워드) Photodynamic therapy , Mesenchymal stem cells , Tumor targeting , Activatable photosensitizer , Precision medicine
- 주제(기타) Engineering, Biomedical; Materials Science, Biomaterials
- 설명문(일반) [Li, Xingshu; Lee, Dayoung; Kim, Gyoungmi; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea; [Kim, C-yoon; Chung, Hyung-Min; Hong, Ki-Sung] Konkuk Univ, Sch Med, Dept Stem Cell Biol, Seoul 143701, South Korea; [Shin, Jeong Min] CHA Univ, Dept Biotechnol, Seongnam 13488, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCI LTD
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155986
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.biomaterials.2018.09.041
초록/요약
Precise targeting with minimal side effects is of particular interest for personalized medicine, although it remains a challenge. Herein, we demonstrate precision photodynamic therapy (PDT) utilizing human mesenchymal stem cells (MSCs) as cellular vehicles to deliver a new activatable photosensitizer (PcS). In vivo real-time optical imaging tests indicated that PcS-loaded MSCs possess excellent tumor-homing properties. More importantly, dye transfer assays confirm that MSCs precisely transfer PcS into human colon cancer cells (HCT116) via the "bystander effect." Upon localized light irradiation, the growth of intraperitoneal xenograft tumors was significantly inhibited by the photodynamic effect. These findings represent a promising strategy for precise oncotherapy.
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