Self-immolative colorimetric, fluorescent and chemiluminescent chemosensors
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Yan, Jiatao; Zhang, Afang] Shanghai Univ, Coll Mat Sci & Engn, Dept Polymer Mat, Shanghai 200444, Peoples R China; [Lee, Songyi] Pukyong Natl Univ, Dept Chem, Busan 48513, South Korea; [Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155989
- 본문언어 영어
- Published As http://dx.doi.org/10.1039/c7cs00841d
초록/요약
Self-immolative chemistry features a cascade of disassembly reactions in response to external stimuli, which provides great opportunities to design new self-immolative chemosensors with advanced performance and/or functions. Self-immolative spacers in these chemosensors not only facilitate the linkage of designed triggers to various chromophores or fluorophores, but can also be used to solve inherent problems associated with native chemosensors, such as low reactivities, poor stabilities and slow response times. Their capacity for stimuli-responsive release through operation of a self-immolative reaction further enables integration of sophisticated functions into chemosensors, including signal amplification, enzyme activity localization, and drug monitoring. Significant advances have been made in the field of self-immolative chemosensors, leading to intriguing applications to sensitive detection of analytes, bioimaging and cancer theranostics. This tutorial review summarizes this recent progress with a focus on their design strategies and sensing mechanisms.
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