Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy
- 주제(키워드) hypoxia , oxygen delivery , photodynamic therapy , tumors
- 주제(기타) Chemistry, Multidisciplinary
- 설명문(일반) [Li, Xingshu; Kwon, Nahyun; Guo, Tian; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea; [Liu, Zhuang] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China
- 등재 SCIE, SCOPUS
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155990
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/anie.201805138
초록/요약
Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.
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