Ratiometric Two-Photon Fluorescent Probe for Detecting and Imaging Hypochlorite
- 주제(기타) Chemistry, Analytical
- 설명문(일반) [Pak, Yen Leng; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea; [Park, Sang Jun; Kim, Hwan Myung] Ajou Univ, Dept Energy Syst Res, Suwon 443749, Gyeonggi Do, South Korea; [Xu, Qingling] Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155991
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acs.analchem.8b02195
초록/요약
The ratiometric fluorescent probe B6S, which contains pyrene as a fluorophore and imidazoline-2-thione as a reactive site, was developed for detection of hypochlorite (OCl-). B6S displays a high specificity toward OCl(- )in contrast to other reactive oxygen species and reactive nitrogen species. The probe has a low detection limit and operates under biological conditions. Moreover, the low cytotoxicity of B6S enables it to be utilized effectively for OCl- imaging in living cells and tissues by using two-photon microscopy. The findings indicate that B6S has the capability of serving as a probe to explore the biological functions of OCl- in living systems.
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