Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy
- 주제(키워드) nanodots , photodynamic therapy , phthalocyanine , reactive oxygen species , type I photoreactions
- 후원정보 National Research Foundation of Korea
- 등재 SCIE, SCOPUS
- 발행기관 Wiley-VCH Verlag
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000155993
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/anie.201806551
초록/요약
Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super-quenched, thus, preventing their use in photodynamic therapy (PDT). Although some of these materials undergo stimuli-responsive disassembly, which leads to partial recovery of PDT activity, their therapeutic potentials are unsatisfactory owing to a limited ability to promote generation reactive oxygen species (ROS), especially via type I photoreactions (i.e., not by 1O2 generation). Herein we demonstrate that a new, nanostructured phthalocyanine assembly, NanoPcA, has the ability to promote highly efficient ROS generation via the type I mechanism. The results of antibacterial studies demonstrate that NanoPcA has potential PDT applications. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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