Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis
- 주제(키워드) Anastomosis , chitosan , PDS suture , tensile strength , Vicryl suture , wound healing
- 주제(기타) Emergency Medicine
- 설명문(일반) [Altinel, Yuksel; Ozturk, Ersin; Ozguc, Halil] Uludag Univ, Fac Med, Dept Gen Surg, Bursa, Turkey; [Chung, Soon Soup] Ewha Womans Univ, Med Fac, Dept Gen Surg, Seoul, South Korea; [Okay, Guven] Uludag Univ, Fac Med, Dept Biostat, Bursa, Turkey; [Ugras, Nesrin] Uludag Univ Hosp, Dept Pathol, Bursa, Turkey; [Isik, Ahmet Fatih] Uludag Univ, Fac Text Engn, Dept Text, Bursa, Turkey
- 등재 SCIE, SCOPUS
- 발행기관 TURKISH ASSOC TRAUMA EMERGENCY SURGERY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156065
- 본문언어 영어
- Published As http://dx.doi.org/10.5505/tjtes.2018.59280
초록/요약
BACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healing effect. METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan was applied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl, PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7th and 14th days, eight rats from each group were euthanized. RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl-chitosan was lower than PDS-chitosan on the 14th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coated Vicryl were lower than Vicryl and chitosan-coated PDS on the 14th day (p<0.05). The tensile strength of Vicryl-chitosan increased more than Vicryl in vitro (p<0.05) on the 14th and 7th days, but there was no difference in vivo. The tensile strength of PDS-chitosan decreased more than PDS on the 7th day in vivo (p<0.05). CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro and PDS in vivo was slightly improved.
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