Effect of Physical Activity on the Progression of Alzheimer's Disease: The Clinical Research Center for Dementia of South Korea Study
- 주제(키워드) Alzheimer's disease , dementia , physical activity , progression , mortality
- 주제(기타) Neurosciences
- 설명문(일반) [Minn, Yang-Ki] Hallym Univ, Coll Med, Kangnam Sacred Heart Hosp, Dept Neurol, Seoul, South Korea; [Choi, Seong Hye; Choi, Seok-Jin] Inha Univ, Sch Med, Dept Neurol, Incheon, South Korea; [Suh, Young Ju] Inha Univ, Sch Med, Dept Biomed Sci, Incheon, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Mokdong Hosp, Dept Neurol, Seoul, South Korea; [Kim, Eun-Joo] Pusan Natl Univ, Sch Med, Pusan Natl Univ Hosp, Dept Neurol, Busan, South Korea; [Kim, Jong Hun] Natl Hlth Insurance Serv Ilsan Hosp, Dept Neurol, Goyang, South Korea; [Park, Kyung Won] Dong A Univ, Coll Med, Dong A Med Ctr, Dept Neurol, Busan, South Korea; [Park, Moon Ho] Korea Univ, Coll Med, Ansan Hosp, Dept Neurol, Ansan, South Korea; [Youn, Young Chul] Chung Ang Univ, Coll Med, Dept Neurol, Seoul, South Korea; [Yoon, Bora] Konyang Univ, Coll Med, Dept Neurol, Daejeon, South Korea; [Oh, Youn Kyung] Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea; [Yoon, Soo Jin] Eulji Univ, Sch Med, Dept Neurol, Daejeon, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 IOS PRESS
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156160
- 본문언어 영어
- Published As http://dx.doi.org/10.3233/JAD-180333
초록/요약
Background: There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD). Objectives: We investigated whether PA is associated with progression of dementia and mortality in AD. Methods: In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations. Results: Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95% CI = -0.824 similar to-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656 similar to-0.639; p < 0.001) for the high PA group (>750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with >= 150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with <150 minutes per week for each of the PAs (hazard ratio 0.22, 95% CI = 0.05 similar to 0.88; p = 0.033). Conclusion: More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD.
more