A comparative study of the antithrombotic effect through activated endothelium of garlic powder and tomato extracts using a rodent model of collagen and epinephrine induced thrombosis
- 주제(키워드) Activate partial thromboplastin time , Anti-thrombotic effect , Garlic , Intracellular adhesion molecule-1 , Mixture of garlic and tomato , Tomato
- 주제(기타) Food Science & Technology
- 설명문(일반) [Kim, Leeseon; Kim, Ji Yeon] Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, Seoul 01811, South Korea; [Lim, Yeni; Park, Soo-yeon; Kim, You Jin; Kwon, Oran] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea; [Lee, Jin Hee] CHA Univ, Dept Food Sci & Biotechnol, Seongnam 13488, Gyeonggido, South Korea; [Shin, Jae-Ho] Eulji Univ, Dept Biomed Lab Sci, Seongnam 13135, Gyeonggido, South Korea; [Yang, Yoon Kyoung] Soongeui Womens Coll, Dept Nutr Sci & Food Management, Seoul 04628, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156326
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10068-018-0469-z
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
In this study, garlic powder, tomato extract and a mixture of both were analyzed for anti-thrombotic effects using a collagen and epinephrine induced thrombosis model. Rats were randomly assigned to control, thrombosis induced control (COL/EP), garlic powder (G), tomato extract (T) and mixture of garlic powder and tomato extract (GT) groups. Test materials were administered for 7days and thrombosis was induced by collagen and epinephrine injection. The results showed that G, T, and GT delayed activated partial thromboplastin time and reduced the expression of intracellular adhesion molecule-1 mRNA. Histological analysis of aorta and lung revealed that thrombosis was partially improved by G, T, and GT. Although there was no synergistic effect in GT compared to G and T treatment, this study showed that G, T, and GT have anti-thrombotic effect.
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