Multivitamin and mineral supplementation containing phytonutrients scavenges reactive oxygen species in healthy subjects: A randomized, double-blinded, placebo-controlled trial
- 주제(키워드) Antioxidant capacity , DNA damage , Human clinical study , Phytonutrients , ROS scavenging
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, Green Published, gold
- 발행기관 MDPI AG
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000156330
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/nu11010101
- PubMed https://pubmed.ncbi.nlm.nih.gov/30621298
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Phytonutrients and vitamin and mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined the antioxidant and DNA protection capacity of a plant-based, multi-vitamin/mineral, and phytonutrient (PMP) supplementation in healthy adults who were habitually low in the consumption of fruits and vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, and placebo-controlled trial. PMP supplementation for eight weeks reduced reactive oxygen species (ROS) and prevented DNA damage without altering endogenous antioxidant system. Plasma vitamins and phytonutrients were significantly correlated with ROS scavenging and DNA damage. In addition, gene expression analysis in PBMC showed subtle changes in superoxide metabolic processes. In this study, we showed that supplementation with a PMP significantly improved ROS scavenging activity and prevented DNA damage. However, additional research is still needed to further identify mechanisms of actions and the role of circulating phytonutrient metabolites. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
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