Pharmacology of natural radioprotectors
- 주제(키워드) Natural compounds , Toxicity , Mechanisms , Radioprotectors
- 주제(기타) Chemistry, Medicinal; Pharmacology & Pharmacy
- 설명문(일반) [Mun, Gil-Im; Kim, Seoyoung; Choi, Eun; Lee, Yun-Sil] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 120750, South Korea; [Kim, Cha Soon] Korea Hydro & Nucl Power CO LTD, Radiat Hlth Inst, 172 Dolmr Ro, Seongnam Si 13605, Gyeonggi Do, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 PHARMACEUTICAL SOC KOREA
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156476
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-018-1083-6
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Radiotherapy is one of the most efficient ways to treat cancer. However, deleterious effects, such as acute and chronic toxicities that reduce the quality of life, may result. Naturally occurring compounds have been shown to be non-toxic over wide dose ranges and are inexpensive and effective. Additionally, pharmacological strategies have been developed that use radioprotectors to inhibit radiation-induced toxicities. Currently available radioprotectors have several limitations, including toxicity. In this review, we present the mechanisms of proven radioprotectors, ranging from free radical scavenging (the best-known mechanism of radioprotection) to molecular-based radioprotection (e.g., upregulating expression of heat shock proteins). Finally, we discuss naturally occurring compounds with radioprotective properties in the context of these mechanisms.
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