Rapid, specific, and ultrasensitive fluorogenic sensing of phosgene through an enhanced PeT mechanism
- 주제(키워드) BODIPY , Fluorescent turn-on probe , Phosgene , Photoinduced electron transfer (PeT) , Sensing
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier B.V.
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000156545
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.snb.2018.12.017
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
We report the design of an enhanced PeT-based fluorogenic phosgene probe 1-CN comprising a BODIPY fluorescence reporter, and a catechol quencher at the meso-position acting as the phosgene reaction site. The fluorescent catechol-derived probe 1-CN specifically reacts with phosgene to result in a cyclic carbonate ester. The fast (< 3 s) reaction suppresses a reductive PeT quenching process, leading to a fluorescence turn-on signal (F/F0 up to ca. 1300). The high sensitivity (LOD = 24 pM) of the probe is achieved by the precise adjustment of the energy levels of the frontier orbitals involved in the PeT. © 2018 Elsevier B.V.
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