Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells
- 주제(키워드) Angelica tenuissima , decursin , Z-ligustilide , anti-melanogenic activity , Aspergillus oryzae , fermentation
- 주제(기타) Biotechnology & Applied Microbiology; Microbiology
- 설명문(일반) [Park, Yuna; Lee, Jin Woo; Namkoong, Seung; Sohn, Eun-Hwa] Kangwon Natl Univ, Coll Hlth Sci, Samcheok 25949, South Korea; [Kim, Dayoung; Choi, Bomee; Nam, Sang-Jip] Ewha Womans Univ, Dept Chem & Nano Sci, Global Top 5 Program, Seoul 03760, South Korea; [Yang, Inho] Korea Maritime & Ocean Univ, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea; [Koo, Hyun Jung] Korea Natl Coll Agr & Fisheries, Dept Med & Ind Crops, Jeonju 54874, South Korea; [Lee, Sung Ryul] Inje Univ, Dept Convergence Biomed Sci, Coll Med, Cardiovasc & Metab Dis Ctr, Busan 47392, South Korea; [Park, Myung Rye; Lim, Hyosun; Kim, Youn Kyu] Korea Res Inst Bio Sci Co Ltd, Yeoju 12668, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156654
- 본문언어 영어
- Published As http://dx.doi.org/10.4014/jmb.1812.02044
초록/요약
The anti-melanogenic effects of the extract of Angelica tenuissima (AT) root and the extract of AT root fermented by Aspergillus oryzae (FAT) were investigated. These effects were determined by measuring the inhibitory activity of AT and FAT on melanin production in B16F10 melanocytes and with in vitro tyrosinase activity assays. The AT extract inhibited melanin production at concentrations above 250 mu g/ml, and this inhibitory effect was significantly enhanced by the fermentation process with A. oryzae. HPLC analysis resulted in the isolation of two active compounds from both the AT and FAT extracts. Their chemical structures were identified as decursin and Z-ligustilide through comparison with previously reported NMR data. The decursin and Z-ligustilide contents were increased in the FAT extract and could be responsible for its enhanced inhibitory effects on melanin production and tyrosinase activity compared with that of the AT extract.
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