Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist
- 등재 SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156659
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acsomega.7b01689
초록/요약
The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine. © 2018 American Chemical Society.
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