Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditions
- 주제(키워드) Amidation , Aldehydes , Dibromoisocyanuric acid , Acyl bromide
- 주제(기타) Chemistry, Organic
- 설명문(일반) [Kang, Soosung] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Kang, Soosung] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ, Med Sch & Hosp, Mol Imaging & Therapeut Med Res Ctr, Dept Nucl Med, Jeonju 54907, South Korea; [Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ, Chonbuk Natl Univ Hosp, Biomed Res Inst, Res Inst Clin Med, Jeonju 54907, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 PERGAMON-ELSEVIER SCIENCE LTD
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156765
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.tetlet.2018.08.026
초록/요약
A facile method for the direct synthesis of amides from aldehydes is described. Amide bonds were synthesized by an oxidative amidation in the presence of dibromoisocyanuric acid (DBI). Treatment of aromatic and aliphatic aldehydes with dibromoisocyanuric acid generated acyl bromide intermediates, which were employed to react with a variety of secondary and primary amines to give amides. Through this reaction method, various amides were synthesized directly from aldehydes under mild conditions in high yields and short times. This facile and efficient procedure provides potential strategy for the direct synthesis of amides from aldehydes. (C) 2018 Elsevier Ltd. All rights reserved.
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