Radiation Therapy for Anal Squamous Cell Carcinoma: A Retrospective Multicenter Study
- 주제(키워드) Anal cancer , radiotherapy , treatment outcome , pattern of failure , prognostic factor
- 주제(기타) Oncology
- 설명문(일반) [Koh, Hyeon Kang] Konkuk Univ, Dept Radiat Oncol, Med Ctr, Seoul, South Korea; [Kim, Kyubo] Ewha Womans Univ, Dept Radiat Oncol, Coll Med, 1071 Anyangcheon Ro Yangcheon Gu, Seoul 07985, South Korea; [Il Jang, Won; Kim, Mi-Sook] Korea Inst Radiol & Med Sci, Dept Radiat Oncol, 75 Nowon Ro, Seoul 01812, South Korea; [Song, Chang Hoon] Seoul Natl Univ, Dept Radiat Oncol, Bundang Hosp, Seongnam Si, South Korea; [Chang, Ah Ram] Soonchunhyang Univ, Seoul Hosp, Dept Radiat Oncol, Coll Med, Seoul, South Korea; [Park, Hae Jin] Hanyang Univ, Dept Radiat Oncol, Coll Med, Seoul, South Korea; [Kim, Kyung Su] Dongnam Inst Radiol & Med Sci, Dept Radiat Oncol, Busan, South Korea; [Chang, Ji Hyun] Seoul Metropolitan Govt, Seoul Natl Univ, Dept Radiat Oncol, Boramae Med Ctr, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 INT INST ANTICANCER RESEARCH
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156836
- 본문언어 영어
- Published As http://dx.doi.org/10.21873/anticanres.13071
초록/요약
Aim: To analyze the treatment outcomes, patterns of failures and prognostic factors for patients with anal cancer treated with radiotherapy (RT). Materials and Methods: Between January 2000 and December 2015, 83 patients with anal squamous cell carcinoma were treated with definitive RT. The median RT dose applied to the primary carcinoma site was 55 (range=45-64) Gy. Seventy-six patients (91.6%) received concurrent chemotherapy, and the most common regimen was 5-fluorouracil plus mitomycin C. Results: The median age of patients was 64 (range=36-86) years, and there were 21 males and 62 females. The overall complete remission rate was 89.2%. The median duration of follow-up was 51 (range=3173) months. The actuarial 5-year overall, progression-free survival (PFS), locoregional progression-free, and distant metastasis-free survival rates were 85.0%, 70.4%, 78.2%, and 82.6%, respectively. On multivariate analysis, eventual treatment response was the only prognostic factor for overall (p=0.023) and progression-free (p<0.001) survival. Age (p=0.013) and eventual treatment response (p<0.001) were significantly associated with locoregional progression-free survival. Initial treatment response, lymph node involvement and RT technique significantly affected distant metastasis-free survival (p=0.016, 0.048 and 0.002, respectively). Conclusion: RT, mainly with concurrent chemotherapy, showed acceptable treatment outcomes and safe toxicity profiles.
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