Malignant and borderline phyllodes tumors of the breast: a multicenter study of 362 patients (KROG 16-08)
- 주제(키워드) Malignant phyllodes tumor , Borderline phyllodes tumor , Breast neoplasm , Adjuvant therapy , Recurrence , Risk factor
- 주제(기타) Oncology
- 설명문(일반) [Choi, Noorie; Shin, Kyung Hwan] Seoul Natl Univ, Dept Radiat Oncol, Coll Med, Seoul, South Korea; [Kim, Kyubo] Ewha Womans Univ, Dept Radiat Oncol, Sch Med, Seoul, South Korea; [Kim, Yumi; Moon, Hyeong-Gon] Seoul Natl Univ, Dept Surg, Coll Med, Seoul, South Korea; [Park, Won; Choi, Doo Ho] Sungkyunkwan Univ, Dept Radiat Oncol, Samsung Med Ctr, Sch Med, Seoul, South Korea; [Kim, Su Ssan; Ahn, Seung Do] Univ Ulsan, Dept Radiat Oncol, Asan Med Ctr, Coll Med, Seoul, South Korea; [Kim, Tae Hyun] Natl Canc Ctr, Res Inst & Hosp, Proton Therapy Ctr, Goyang, South Korea; [Chun, Mison] Ajou Univ, Dept Radiat Oncol, Sch Med, Suwon, South Korea; [Kim, Yong Bae] Yonsei Univ, Dept Radiat Oncol, Yonsei Canc Ctr, Coll Med, Seoul, South Korea; [Kim, Suzy] Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Radiat Oncol, Seoul, South Korea; [Choi, Byung Ock] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Radiat Oncol, Seoul, South Korea; [Kim, Jin Hee] Keimyung Univ, Dept Radiat Oncol, Dongsan Med Ctr, Sch Med, Daegu, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156841
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10549-018-4838-3
초록/요약
Purpose To identify risk factors for local recurrence (LR) and investigate roles of adjuvant local therapy for malignant and borderline phyllodes tumors of the breast. Methods From 1981 to 2014, 362 patients with malignant (n = 235) and borderline (n = 127) phyllodes tumors were treated by breast-conserving surgery (BCS) or total mastectomy (TM) at 10 centers. Thirty-one patients received adjuvant radiation therapy (RT), and those who received adjuvant chemotherapy were excluded from the study. Results Median follow-up was 5 years. LR developed in 60 (16.6%) patients. Regional recurrence occurred in 2 (0.6%) patients and distant metastasis (DM) developed in 19 (5.2%) patients. Patients receiving BCS (p = 0.025) and those not undergoing adjuvant RT (p = 0.041) showed higher LR rates. For malignant subtypes, local control (LC) rates at 5 years for BCS alone, BCS with adjuvant RT, TM alone, and TM with adjuvant RT were 80.7, 93.3, 92.4, and 100%, respectively (p = 0.033). Multivariate analyses revealed BCS alone, tumor size >= 5 cm, and positive margins as independent risk factors for LR. Margin-positive BCS alone showed poorest LC regardless of tumor size (62.5%, p = 0.007). For margin-negative BCS alone, 5-year LC rates for tumors >= 5 cm versus those < 5 cm were 71.8% versus 89.5% (p = 0.012). For borderline subtypes, only positive margins (p = 0.044) independently increased the risk of LR. DM developed exclusively in malignant subtypes and a prior LR event increased the risk of DM by sixfold (HR 6.2, 95% CI 1.6-16.1, p = 0.001). Conclusions Malignant and borderline phyllodes tumors with positive margins after surgery have high LR rates. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors >= 5 cm also have heightened risk of LR. Thus, such patients should be considered for additional local therapy.
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