Recent advances in metabolic engineering of Corynebacterium glutamicum as a potential platform microorganism for biorefinery
- 주제(키워드) Corynebacterium glutamicum , biorefinery , metabolic engineering , microbial cell factory , carbon utilization , biomass , consolidated bioprocess , polyamide
- 주제(기타) Biotechnology & Applied Microbiology; Energy & Fuels
- 설명문(일반) [Baritugo, Kei-Anne G.; David, Yokimiko C.; Park, Si Jae] Ewha Womans Univ, Div Chem Engn & Mat Sci, Seoul, South Korea; [Kim, Hee Taek; Joo, Jeong Chan] Korea Res Inst Chem Technol, Adv Convergent Chem Div, Biobased Chem Res Ctr, Daejeon, South Korea; [Choi, Jong Hyun] Korea Res Inst Biosci & Biotechnol, Microbial Biotechnol Res Ctr, Jeonbuk Branch Inst, Jeonbuk, South Korea; [Choi, Jong-il; Kim, Tae Wan] Chonnam Natl Univ, Dept Biotechnol & Bioengn, Gwangju, South Korea; [Park, Chulhwan] Kwangwoon Univ, Dept Chem Engn, Seoul, South Korea; [Hong, Soon Ho] Univ Ulsan, Dept Chem Engn, Ulsan, South Korea; [Na, Jeong-Geol] Sogang Univ, Dept Chem & Biomol Engn, Seoul, South Korea; [Jeong, Ki Jun] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, PLUS Program BK21, Daejeon, South Korea
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 WILEY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156900
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/bbb.1895
초록/요약
The fermentative production of platform chemicals in biorefineries is a sustainable alternative to current petroleum-refining processes. Industrial microorganisms, such as Escherichia coli, Saccharomyces cerevisiae, and Corynebacterium glutamicum, have been engineered as microbial cell factories that are able to utilize biomass for the production of value-added platform chemicals and polymers. Compared to E. coli and S. cerevisiae, C. glutamicum displays weak carbon catabolite repression and can co-utilize mixed sugars as carbon sources, without any significant growth retardation. Pathways for the utilization of alternative carbon sources, such as d-xylose and l-arabinose from lignocellulosic biomass, lactose and galactose from whey, glycerol from biodiesel, and methanol from natural gas refineries, have been evaluated for chemical production. However, the application of C. glutamicum in biorefineries is limited because it does not secrete hydrolases for the efficient utilization of cellulose, xylan, and starch from lignocellulosic and starch biomass. To solve the limitation, C. glutamicum has been engineered for the consolidated bioprocessing of biomass by the heterologous expression of amylolytic and cellulolytic enzymes. Recently, C. glutamicum has been extensively engineered for polyamide monomer production owing to its ability to produce l-lysine and l-glutamate. This review summarizes recent advances in the development of C. glutamicum strains that can utilize renewable biomass resources for the production of industrially important chemicals. It highlights recent progress in metabolic engineering for the production of polyamide monomers. (c) 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
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