Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic Neurotransmission in the Striatum of C57BL/6 Mice
- 주제(키워드) Arsenic , Glutamate , mGluR2 , mGluR3 , Striatum , VGLUT2
- 관리정보기술 faculty
- 등재 SCIE, SCOPUS
- 발행기관 Humana Press Inc.
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000156922
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12011-018-1374-2
- PubMed https://pubmed.ncbi.nlm.nih.gov/29748927
초록/요약
Although exposure to arsenic (As) induces developmental neurotoxicity, there is a lack of data regarding its specific effects on glutamatergic neurotransmission in offspring from dams exposed to As during gestation and lactation. In this study, the body weight, glutamate content, and expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic glutamate receptors mGluR2 and mGluR3 was examined in the striatum of offspring following treatment of the dams with As (10 or 100 mg/L NaAsO2 in drinking water). At postnatal day 21, body weight was decreased significantly, whereas the glutamate content in the striatum of offspring in the 100-mg/L As group were not significantly different from those in the control group. Although mGluR3 expression was not significantly different, VGLUT2 and mGluR2 expression was significantly lower in the striatum of offspring of As-exposed dams. These data indicate that altered glutamatergic neurotransmission may contribute to As-induced developmental neurotoxic effects. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
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