Pioneering Effects and Enhanced Neurite Complexity of Primary Hippocampal Neurons on Hierarchical Neurotemplated Scaffolds
- 주제(키워드) axonal pathfinding , hierarchical topographies , neurite complexity , neurotemplated scaffolds , pioneer neurons
- 주제(기타) Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials
- 설명문(일반) [Kim, Beom Jin; Park, Matthew; Joo, Sunghoon; Kim, Mi-Hee; Choi, Insung S.] Korea Adv Inst Sci & Technol, Dept Chem, Ctr Cell Encapsulat Res, Daejeon 34141, South Korea; [Park, Ji Hun] Ewha Womans Univ, Dept Sci Educ, Seoul 03760, South Korea; [Kang, Kyungtae] Kyung Hee Univ, Dept Appl Chem, Yongin 17104, Gyeonggi, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 WILEY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156964
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/adhm.201800289
초록/요약
In this work, the use of scaffolds is reported, templated from live neurons as an advanced culture platform for primary neurons. Hippocampal neurons cultured on neurotemplated scaffolds exhibit an affinity for templated somas, revealing a preference for micrometric structures amidst nanotopographical features. It is also reported, for the first time, that neurite complexity can be topographically controlled by increasing the density of nanometric features on neurotemplated scaffolds. Neurotemplated scaffolds are versatile, hierarchical topographies that feature biologically relevant structures, in both form and scale, and capture the true complexity of an in vivo environment. The introduction and implementation of neurotemplated scaffolds is sure to advance research in the fields of neurodevelopment, network development, and neuroregeneration.
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