Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo
- 주제(기타) Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied
- 설명문(일반) [Park, Ji Hun; Arsiwala, Ammar; Kane, Ravi S.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA; [Dumani, Diego S.; Emelianov, Stanislav] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30332 USA; [Dumani, Diego S.; Emelianov, Stanislav] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA; [Dumani, Diego S.; Emelianov, Stanislav] Emory Univ, Sch Med, Atlanta, GA 30307 USA; [Park, Ji Hun] Ewha Womans Univ, Dept Sci Educ, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 ROYAL SOC CHEMISTRY
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000156965
- 본문언어 영어
- Published As http://dx.doi.org/10.1039/c8nr03973a
초록/요약
Photoacoustic imaging using exogenous contrast agents has emerged as a hybrid technique that enables the deep imaging of optical properties of tissues with high spatial resolution. The power of this imaging technique can be greatly enhanced by the use of contrast agents that absorb at near-infrared wavelengths and whose optical properties can be modulated in response to the local environment. We have designed contrast agents consisting of gold nanoparticles coated with anisotropic silica nanoshells. The tunable aggregation of these Janus particles in cell culture media resulted in a dramatic amplification of photoacoustic signals in the near-infrared region. We also demonstrated imaging using these contrast agents in mammalian cells, including macrophages and breast cancer cells as well as in vivo. The ability to modulate Janus particle aggregation in response to a range of stimuli in combination with the high resolution and deep penetration of multiwavelength photoacoustic imaging are attractive for a broad range of applications in diagnostic imaging and theranostics.
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