Alterations of the Gut Microbiome in Chronic Hepatitis B Virus Infection Associated with Alanine Aminotransferase Level
- 주제(키워드) hepatitis B virus , gut microbiome , Megasphaera
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Yun, Yeojun] Syntekabio Inc, Gwanghwamun Med Study Ctr, Seoul 03186, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Occupat & Environm Med, Seoul 04514, South Korea; [Chang, Yoosoo; Kim, Han-Na; Ryu, Seungho; Kwon, Min-Jung] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Ctr Cohort Studies,Sch Med, Seoul 04514, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul 06351, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Med Res Inst, Seoul 03181, South Korea; [Kwon, Min-Jung] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Lab Med, Sch Med, Seoul 03181, South Korea; [Cho, Yong Kyun] Sungkyunkwan Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med,Kangbuk Samsung Hosp, Seoul 03181, South Korea; [Kim, Hyung-Lae] Ewha Womans Univ, Coll Med, Dept Biochem, Seoul 07985, South Korea; [Cheong, Hae Suk; Joo, Eun-Jeong] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Infect Dis,Sch Med, Seoul 03181, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, gold, Green Published
- 발행기관 MDPI
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159725
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm8020173
- PubMed https://pubmed.ncbi.nlm.nih.gov/30717396
초록/요약
The changes in the gut microbiota of healthy hepatitis B virus (HBV) carriers, including asymptomatic and non-cirrhotic subjects, have been rarely scrutinized. From 1463 faecal samples in health examinees, in total 112 subjects, including 36 hepatitis B surface antigen (HBsAg)-positive and 76 control subjects, were included. Twenty-eight of 36 HBsAg-positive individuals (78%) showed normal alanine aminotransferase (ALT) levels (normal ALT group), whereas eight subjects exhibited elevated ALT levels (22%, high ALT group). By using 16S rRNA gene sequencing, the distance between normal and high ALT groups among HBsAg-positive subjects showed a significant separation after the pairwise comparison of weighted UniFrac distance (permutational analysis of variance q-value = 0.039), when compared with the distances to the control group. In comparison with the control group, the normal ALT group had Anaerostipes as a significant taxon that showed a positive association (Coefficient (Coef.) = 0.028, q = 0.039). Desulfovibrio (Coef. = 0.54, q = 0.014) and Megasphaera (Coef. = 1.41, q = 0.030) showed positive correlations, and Acidaminococcus (Coef. = -1.31, q = 4.15 x 10(-75)) exhibited a negative correlation with high ALT level. Gut microbial composition was different according to HBV-induced serum ALT levels, indicative of a potential link between gut and liver metabolism.
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