Fructose and sugar: A major mediator of non-alcoholic fatty liver disease
- 주제(키워드) Hepatic steatosis , Hepatic inflammation , Insulin resistance , Sugar consumption , Uric acid
- 주제(기타) Gastroenterology & Hepatology
- 설명문(일반) [Jensen, Thomas; Sullivan, Shelby; Roncal, Carlos; Kuwabara, Masanari; Sato, Yuka; Rosen, Hugo R.; Lanaspa, Miguel A.; Johnson, Richard J.] Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA; [Abdelmalek, Manal F.; Diehl, Anna Mae] Duke Univ, Durham, NC USA; [Nadeau, Kristen J.; Green, Melanie] Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO USA; [Nakagawa, Takahiko] Nara Med Univ, Div Future Basic Med, Nara, Japan; [Kang, Duk-Hee] Ewha Womans Univ, Coll Med, Dept Internal Med, Div Nephrol, Seoul, South Korea; [Tolan, Dean R.] Boston Univ, Dept Biol, 5 Cummington St, Boston, MA 02215 USA; [Sanchez-Lozada, Laura G.] INC Ignacio Chavez, Lab Renal Physiopathol, Mexico City, DF, Mexico
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE BV
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000159747
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.jhep.2018.01.019
초록/요약
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome; its rising prevalence parallels the rise in obesity and diabetes. Historically thought to result from overnutrition and a sedentary lifestyle, recent evidence suggests that diets high in sugar (from sucrose and/or high-fructose corn syrup [HFCS]) not only increase the risk of NAFLD, but also non-alcoholic steatohepatitis (NASH). Herein, we review the experimental and clinical evidence that fructose precipitates fat accumulation in the liver, due to both increased lipogenesis and impaired fat oxidation. Recent evidence suggests that the predisposition to fatty liver is linked to the metabolism of fructose by fructokinase C, which results in ATP consumption, nucleotide turnover and uric acid generation that mediate fat accumulation. Alterations to gut permeability, the microbiome, and associated endotoxemia contribute to the risk of NAFLD and NASH. Early clinical studies suggest that reducing sugary beverages and total fructose intake, especially from added sugars, may have a significant benefit on reducing hepatic fat accumulation. We suggest larger, more definitive trials to determine if lowering sugar/HFCS intake, and/or blocking uric acid generation, may help reduce NAFLD and its downstream complications of cirrhosis and chronic liver disease. (C) 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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