Comparison of Immune Responses to Two Quadrivalent Meningococcal Conjugate Vaccines (CRM197 and Diphtheria Toxoid) in Healthy Adults
- 주제(키워드) Immunogenicity , Meningococcal Vaccines , Adult
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Kim, Han Wool; Lee, Soyoung; Lee, Ji Hyen; Kim, Kyung-Hyo] Ewha Womans Univ, Coll Med, Dept Pediat, 1071 Anyangcheon Ro, Seoul 07985, South Korea; [Kim, Han Wool; Lee, Soyoung; Lee, Ji Hyen; Kim, Kyung-Hyo] Ewha Womans Univ, Coll Med, Ctr Vaccine Evaluat & Study, Seoul, South Korea; [Woo, So-Youn] Ewha Womans Univ, Coll Med, Dept Microbiol, Seoul, South Korea; [Lee, Soyoung] Seoul Natl Univ Hosp, Dept Pediat, Div Immunol, Seoul, South Korea
- OA유형 Green Published, Green Submitted, gold
- 발행기관 KOREAN ACAD MEDICAL SCIENCES
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159763
- 본문언어 영어
- Published As http://dx.doi.org/10.3346/jkms.2019.34.e169
- PubMed https://pubmed.ncbi.nlm.nih.gov/31197986
초록/요약
Background: After the introduction of the meningococcal ACWY-CRM197 conjugate vaccine (MenACWY-CRM) in 2012 and the meningococcal ACWY-diphtheria toxoid conjugate vaccine (MenACWY-DT) in 2014, immunization was recommended for certain high-risk groups including new military recruits in Korea. However, comparative immunogenicity studies for these vaccines have not been performed in Korea. Here, we compared the immunogenicity of these two vaccines in healthy adults. Methods: A total of 64 adults, 20-49 years of age, were randomly divided into two groups (1:1) to receive either of the two vaccines. The sera were obtained before and 1 month after vaccination and tested for serogroup-specific serum bactericidal activity using baby rabbit complement. Results: There were no significant differences post-vaccination in the geometric mean indices and the seropositive rate to all serogroups between the vaccines. The proportion of seropositive subjects after vaccination ranged from 88% to 100%. Conclusion: Both meningococcal conjugate vaccines showed good immunogenicity in healthy Korean adults without statistically significant differences. Further investigations for serotype distribution of circulating meningococci and the immune interference between other diphtheria toxin-containing vaccines concomitantly used for military recruits are needed to optimize immunization policies.
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