Clinical subtypes and prognosis in breast cancer according to parity: a nationwide study in Korean Breast Cancer Society
- 주제(키워드) Parity , Breast cancer , Subtype , Prognosis
- 주제(기타) Oncology
- 설명문(일반) [Park, Sungmin] Chungbuk Natl Univ, Coll Med, Chungbuk Natl Univ Hosp, Dept Breast Surg, Cheongju, South Korea; [Moon, Byung In] Ewha Womans Univ, Coll Med, Mokdong Hosp, Dept Breast Surg, Seoul, South Korea; [Oh, Se Jeong] Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Dept Surg, Incheon Si, South Korea; [Lee, Han-Byoel] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Breast Surg, Seoul, South Korea; [Seong, Min-Ki] Korea Canc Ctr Hosp, Korea Inst Radiol & Med Sci, Dept Surg, Seoul, South Korea; [Lee, Seokwon] Pusan Natl Univ Hosp, Biomed Res Inst, Dept Surg, Busan, South Korea; [Byun, Kyung Do] Dong A Univ, Dong A Univ Hosp, Coll Med, Dept Surg, Busan, South Korea; [Jung, Seung Pil; Bae, Soo Youn] Korea Univ, Coll Med, Anam Hosp, Div Breast & Endocrine Surg,Dept Surg, 73 Inchon Ro, Seoul 02841, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159795
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s10549-018-5032-3
- PubMed https://pubmed.ncbi.nlm.nih.gov/30390214
초록/요약
PurposeWe explored the association between parity and the risk of developing a specific subtype of breast cancer. We also assessed the association between parity and prognosis according to subtypes.MethodsA total of 158,189 patients were enrolled in the Korean Breast Cancer Society Registry database between 1996 and 2015 in Korea. The database provided information on sex, age, number of parity, surgical method, stage, histological findings, presence of biologic markers, adjuvant therapy, and date and cause of death.ResultsThe patients with higher parity showed a higher ratio of triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER2) subtypes. In univariate analysis, women with TNBC who had more than three children had a worse prognosis compared to other groups (HR 1.83; 95% CI 1.34-2.49; P<0.001). This association was also observed in women younger than 50years (HR 1.63; 95% CI 1.07-2.48; P=0.021). In multivariate analysis stratified by subtypes, women who had more than three children were associated with a worse prognosis in TNBC in the total population (HR 1.53; 95% CI 1.11-2.12; P=0.011). This association was also observed in patients younger than 50years of age (HR 1.53; 95% CI 1.09-2.61; P=0.017).ConclusionWomen who had more than three children were more likely to develop hormone receptor-negative (HR-) subtypes. Women who had more than three children were associated with worse prognosis in patients younger than 50years of age and in patients with TNBC.
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