Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells
- 주제(키워드) Catalpa ovata , catalpalactone , lipopolysaccharide , NF-kappa B , IRF3
- 주제(기타) Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
- 설명문(일반) [Kim, Hyo-Young; Han, Ah-Reum; Jin, Chang Hyun] Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 56212, South Korea; [Kil, Yun-Seo; Seo, Eun Kyoung] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, Green Published, gold
- 발행기관 MDPI
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159856
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/molecules24071236
- PubMed https://pubmed.ncbi.nlm.nih.gov/30934890
초록/요약
Catalpa ovata (Bignoniaceae) is widely distributed throughout Korea, China, and Japan. This study investigated the anti-inflammatory effects of catalpalactone isolated from C. ovata in lipopolysaccharide (LPS)-induced RAW264.7 cells. Catalpalactone significantly inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in LPS-induced RAW264.7 cells. The levels of cytokines such as interleukin-6 and tumor necrosis factor-alpha were reduced under catalpalactone exposure in LPS-induced RAW264.7 cells. Additionally, catalpalactone suppressed signal transducer and activator of transcription 1 (STAT-1) protein expression and interferon-beta (IFN-beta) production. Treatment with catalpalactone prevented interferon regulatory factor 3 (IRF3) and nuclear factor-kappa B (NF-kappa B) activation. Taken together, these results suggest that the anti-inflammatory effects of catalpalactone are associated with the suppression of NO production and iNOS expression through the inhibition of IRF3, NF-kappa B, and IFN-beta/STAT-1 activation.
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