Altered attentional control over the salience network in complex regional pain syndrome
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Kim, Jungyoon; Kang, Ilhyang; Namgung, Eun; Lee, Suji; Cho, Hanbyul; Kim, Myeong Ju; Kim, Tammy D.; Lyoo, In Kyoon; Yoon, Sujung] Ewha Womnans Univ, Ewha Brain Inst, Seoul, South Korea; [Kim, Jungyoon; Kang, Ilhyang; Namgung, Eun; Lee, Suji; Kim, Myeong Ju; Kim, Tammy D.; Lyoo, In Kyoon; Yoon, Sujung] Ewha Womans Univ, Dept Brain & Cognit Sci, Seoul, South Korea; [Chung, Yong-An; Oh, Jin Kyoung; Jeong, Hyeonseok S.] Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Dept Radiol, Seoul, South Korea; [Kim, Tae-Suk] Catholic Univ Korea, Coll Med, Dept Psychiat, Seoul, South Korea; [Choi, Soo Hyun] Tulane Univ, Sch Sci & Engn, New Orleans, LA 70118 USA; [Lim, Soo Mee] Ewha Womans Univ, Coll Med, Dept Radiol, Seoul, South Korea; [Lyoo, In Kyoon] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 NATURE PUBLISHING GROUP
- 발행년도 2018
- URI http://www.dcollection.net/handler/ewha/000000159877
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41598-018-25757-2
초록/요약
The degree and salience of pain have been known to be constantly monitored and modulated by the brain. In the case of maladaptive neural responses as reported in centralized pain conditions such as complex regional pain syndrome (CRPS), the perception of pain is amplified and remains elevated even without sustained peripheral pain inputs. Given that the attentional state of the brain greatly influences the perception and interpretation of pain, we investigated the role of the attention network and its dynamic interactions with other pain-related networks of the brain in CRPS. We examined alterations in the intra-and inter-network functional connectivities in 21 individuals with CRPS and 49 controls. CRPS-related reduction in intra-network functional connectivity was found in the attention network. Individuals with CRPS had greater inter-network connectivities between the attention and salience networks as compared with healthy controls. Furthermore, individuals within the CRPS group with high levels of pain catastrophizing showed greater inter-network connectivities between the attention and salience networks. Taken together, the current findings suggest that these altered connectivities may be potentially associated with the maladaptive pain coping as found in CRPS patients.
more