The Relationship between Platelet Count and Host Gut Microbiota: A Population-Based Retrospective Cross-Sectional Study
- 주제(키워드) gut microbiota , 16S RNA , platelet , thrombocytosis , Faecalibacterium
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Yoon, Hee-Young; Kim, Soo Jung; Lee, Jin Hwa] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul 07804, South Korea; [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Med Res Inst, Seoul 03181, South Korea; [Lee, Su Hwan] Yonsei Univ, Severance Hosp, Inst Chest Dis, Dept Internal Med,Div Pulmonol,Coll Med, Seoul 03722, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul 04514, South Korea; [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Occupat & Environm Med, Seoul 03181, South Korea; [Shin, Hocheol] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Family Med, Sch Med, Seoul 03181, South Korea; [Kim, Hyung-Lae] Ewha Womans Univ, Coll Med, Dept Biochem, Seoul 07804, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold, Green Submitted
- 발행기관 MDPI
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159891
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm8020230
- PubMed https://pubmed.ncbi.nlm.nih.gov/30744195
초록/요약
Platelet count reflects the severity and prognosis of multiple diseases. Additionally, alterations in gut microbiota have been linked to several chronic diseases. The purpose of this study was to investigate the association between gut microbiota and platelet count. We selected 1268 subjects with fecal 16S RNA gene sequencing data from a Healthcare Screening Center cohort. Based on the third quartile of platelets (277 x 10(9)/L), we compared the gut microbiota between the upper quartile (n = 321) and lower three quartiles groups (n = 947). The upper quartile group had lower alpha diversity based on observed amplicon sequence variants (q = 0.004) and phylogenetic index (q < 0.001) than the lower three quartiles group. Significant differences were also found in the weighted UniFrac distance (q = 0.001) and Jaccard dissimilarity (q = 0.047) beta diversity measures between the two groups. Compared with the lower three quartiles group, the upper quartile group exhibited decreased relative abundances of the genus Faecalibacterium, which was also inversely correlated with the platelet count. Increased platelet count was associated with reduced diversity in gut microbiota and lower abundances of Faecalibacterium with beneficial gut bacteria spices F. prausnitzii, suggesting that an increased platelet count, even within normal range, may adversely affect gut microbial diversity and composition.
more