Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea
- 주제(키워드) Staphylococcus aureus , Panton-Valentine leukocidin , molecular epidemiology
- 주제(기타) Infectious Diseases; Microbiology; Pharmacology & Pharmacy
- 설명문(일반) [Song, Kyoung-Ho; Kim, Eu Suk; Hwang, Joo-Hee; Kim, Hong Bin] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, South Korea; [Song, Kyoung-Ho; Kim, Eu Suk; Hwang, Joo-Hee; Choe, Pyoeng Gyun; Bang, Ji Hwan; Oh, Myoung-don; Kim, Hong Bin] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Park, Kyung-Hwa] Chonnam Natl Univ, Med Sch, Dept Infect Dis, Gwangju, South Korea; [Choi, Hee Jung] Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea; [Kim, Kye-Hyung; Lee, Shinwon] Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; [Lee, Shinwon] Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea; [Hwang, Jeong-Hwan] Chonbuk Natl Univ, Med Sch, Dept Internal Med, Jeonju, South Korea; [Choo, Eun Ju] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Bucheon, South Korea; [Park, Yoonseon] Ilsan Hosp, Natl Hlth Insurance Serv, Dept Internal Med, Goyang, South Korea; [Lee, Eun Jung] Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Seoul, South Korea; [Kim, Young Keun] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea; [Jeon, Min Hyok] Soonchunhyang Univ, Cheonan Hosp, Dept Internal Med, Cheonan, South Korea; [Moon, Chisook] Inje Univ, Coll Med, Dept Internal Med, Busan, South Korea; [Park, Jeong Su; Park, Kyoung Un] Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea; [Bang, Ji Hwan] Seoul Metropolitan Government Seoul Natl Univ Bor, Med Ctr, Div Infect Dis, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MARY ANN LIEBERT, INC
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159895
- 본문언어 영어
- Published As http://dx.doi.org/10.1089/mdr.2018.0238
초록/요약
Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea. Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone. Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.
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