Sequential Protein-Responsive Nanophotosensitizer Complex for Enhancing Tumor-Specific Therapy
- 주제(키워드) nanophotosensitizer , photodynamic therapy , activatable , protein-responsive , phthalocyanine
- 주제(기타) Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
- 설명문(일반) [Li, Xingshu; Fan, Huanhuan; Bai, Huarong; Zhang, Xiao-Bing; Tan, Weihong] Hunan Univ, Collaborat Innovat Ctr Chem & Mol Med, State Key Lab Chemo Biosensing & Chemometr, Mol Sci & Biomed Lab,Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China; [Li, Xingshu; Guo, Tian; Kwon, Nahyun; Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea; [Kim, Kwang H.; Yu, Sungsook; Cho, Yejin; Kim, Hyunji; Nam, Ki Taek] Yonsei Univ, Coll Med, Brain Korea 21 PLUS Project Med Sci, Severance Biomed Sci Inst, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 AMER CHEMICAL SOC
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000159916
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/acsnano.9b01100
- PubMed https://pubmed.ncbi.nlm.nih.gov/31184131
초록/요약
A major challenge in cancer treatment is the development of effective tumor-specific therapeutic methods that have minimal side effects. Recently, a photo dynamic therapy (PDT) technique using activatable photosensitizers (aPSs) has shown great potential for cancer-specific treatment. Here, we develop a sequential protein-responsive aPS (PcC4-MSN-O1) that is based on zinc(II) phthalocyanine derivative (PcC4)-entrapped mesoporous silica nanoparticles (MSNs) and a wrapping DNA (O1) as a biogate. Inside the nanostructure of PcC4-MSN-O1, PcC4 shows self-quenching photoactivity. However, when PcC4-MSN-O1 sequentially reacts with telomerase and albumin, its photoactivity is dramatically turned on. Therefore, PcC4-MSN-O1 displays selective phototoxicity against cancer cells (e.g., HeLa) over normal cells (e.g., HEK-293). Following systemic PcC4-MSN-O1 administration, there is an obvious accumulation in HeLa tumors of xenograft-bearing mice, and laser irradiation clearly induces the inhibition of tumor growth. Moreover, the time-modulated activation process in tumors and the relatively fast excretion of PcC4-MSN-O1 indicate its advantages in reducing potential side effects.
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