Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Danese, Elisa; Montagnana, Martina] Univ Verona, Dept Neurol Biomed & Movement Sci, Clin Biochem Sect, Verona, Italy; [Raimondi, Sara; Tagetti, Angela; Giontella, Alice; Minuz, Pietro; Fava, Cristiano] Univ Verona, Dept Med, Gen Med & Hypertens Unit, Verona, Italy; [Langaee, Taimour; Cavallari, Larisa H.; Shahin, Mohamed Hossam A.; Johnson, Julie A.] Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Ctr Pharmacogen, Gainesville, FL USA; [Borgiani, Paola; Ciccacci, Cinzia] Univ Roma Tor Vergata, Dept Biomed & Prevent, Genet Sect, Rome, Italy; [Carcas, Antonio J.; Borobia, Alberto M.; Tong, Hoi Y.] Univ Autonoma Madrid, La Paz Univ Hosp, IdiPAZ, Clin Pharmacol Dept,Sch Med, Madrid, Spain; [Carcas, Antonio J.; Borobia, Alberto M.; Tong, Hoi Y.] Spanish Clin Res Network SCReN, Madrid, Spain; [Davila-Fajardo, Cristina] San Cecilio Univ Hosp, Inst Biomed Res, IBS, Dept Clin Pharm, Granada, Spain; [Botton, Mariana Rodrigues] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS, Brazil; [Bourgeois, Stephane; Deloukas, Panos] Queen Mary Univ London, Barts & London Med Sch, William Harvey Res Inst, London, England; [Deloukas, Panos] King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia; [Caldwell, Michael D.] Marshfield Clin Fdn Med Res & Educ, Ctr Hyperbar Med & Tissue Repair, Marshfield, WI USA; [Burmester, Jim K.] Gundersen Hlth Syst, Grants Off, La Crosse, WI USA; [Berg, Richard L.] Marshfield Clin Res Fdn, Clin Res Ctr, Marshfield, WI USA; [Drozda, Katarzyna] Univ Illinois, Dept Pharm Practice, Chicago, IL USA; [Huang, Min; Zhao, Li-Zi] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China; [Cen, Han-Jing] Guangzhou Women & Childrens Med Ctr, Guangzhou, Guangdong, Peoples R China; [Gonzalez-Conejero, Rocio; Roldan, Vanessa] Univ Murcia, Hosp Univ Morales Meseguer, Ctr Reg Hemodonac, Murcia, Spain; [Nakamura, Yusuke; Mushiroda, Taisei] RIKEN, Res Grp Pharmacogen, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan; [Gong, Inna Y.; Kim, Richard B.] Univ Western Ontario, Dept Med, Div Clin Pharmacol, London, ON, Canada; [Hirai, Keita; Itoh, Kunihiko] Univ Shizuoka, Sch Pharmaceut Sci, Dept Clin Pharmacol & Genet, Shizuoka, Japan; [Isaza, Carlos; Beltran, Leonardo] Univ Tecnol Pereira, Fac Heath Sci, Lab Med Genet, Pereira, Colombia; [Beltran, Leonardo] Fac Heath Sci, Unidad Cent Valle del Cauca, Valle Del Cauca, Colombia; [Jimenez-Varo, Enrique] Hosp La Linea, Clin Lab Dept, Cadiz, Spain; [Canadas-Garre, Marisa] Queens Univ Belfast, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland; [Kringen, Marianne K.] Oslo Univ Hosp, Dept Pharmacol, Oslo, Norway; [Kringen, Marianne K.] Diakonhjemmet Hosp, Ctr Psychopharmacol, Oslo, Norway; [Haug, Kari Bente Foss] Oslo Univ Hosp, Dept Med Biochem, Oslo, Norway; [Gwak, Hye Sun] Ewha Womans Univ, Coll Pharm, Div Life & Pharmaceut Sci, Seoul, South Korea; [Lee, Kyung Eun] Chungbuk Natl Univ, Coll Pharm, Cheongju, South Korea; [Lee, Ming Ta Michael] Geisinger Hlth Syst, Genom Med Inst, Danville, PA USA; [Lee, Ming Ta Michael] Acad Sinica, Inst Biomed Sci, Natl Ctr Genome Med, Taipei, Taiwan; [Lubitz, Steven A.] Massachusetts Gen Hosp, Cardiac Arrhythmia Serv & Cardiovasc Res Ctr, Boston, MA 02114 USA; [Scott, Stuart] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA; [Mazzaccara, Cristina; Sacchetti, Lucia] CEINGE Biotecnol Avanzate Scarl, Naples, Italy; [Mazzaccara, Cristina; Sacchetti, Lucia] Univ Napoli Federico II, Dipartimento Med Mol & Biotecnol Med, Naples, Italy; [Genc, Ece; Ozer, Mahmut] Yeditepe Univ, Dept Pharmacol, Istanbul, Turkey; [Pathare, Anil] Sultan Qaboos Univ, Coll Med & Hlth Sci, Muscat, Oman; [Krishnamoorthy, Rajagopal] INSERM, UMR S 763, Paris, France; [Paldi, Andras] Ecole Prat Hautes Etud, UMRS 951, Evry, France; [Siguret, Virginie] Univ Paris 05, UMR S 1140, INSERM, Sorbonne Paris Cite, Paris, France; [Siguret, Virginie] Hop Lariboisiere, AP HP, Serv Hematol Biol, Paris, France; [Loriot, Marie-Anne] Univ Paris 05, INSERM, UMR S1147, Sorbonne Paris Cite, Paris, France; [Loriot, Marie-Anne] Hop Europeen Georges Pompidou, AP HP, Serv Biochim Pharmacogenet & Oncol Mol, Paris, France; [Kutala, Vijay Kumar] Nizams Inst Med Sci, Dept Clin Pharmacol & Therapeut, Hyderabad, India; [Suarez-Kurtz, Guilherme] Inst Nacl Canc, Coordenacao Pesquisa, Rio De Janeiro, Brazil; [Perini, Jamila] West Zone State Univ UEZO, Res Lab Pharmaceut Sci, Rio De Janeiro, Brazil; [Denny, Josh C.; Ramirez, Andrea H.] Vanderbilt Univ, Dept Med, Nashville, TN USA; [Denny, Josh C.] Vanderbilt Univ, Dept Biomed Informat, 221 Kirkland Hall, Nashville, TN 37235 USA; [Mittal, Balraj; Rathore, Saurabh Singh] Babasaheb Bhimrao Ambedkar Univ, Dept Biotechnol, Lucknow, Uttar Pradesh, India; [Sagreiya, Hersh; Altman, Russ] Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA; [Khalifa, Sherief, I] Gulf Med Univ, Coll Pharm, Ajman, U Arab Emirates; [Limdi, Nita A.; Rivers, Charles; Dillon, Chrisly] Univ Alabama Birmingham, Dept Neurol, UAB Stn, Birmingham, AL 35294 USA; [Shendre, Aditi] Indiana Univ Purdue Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46202 USA; [Suriapranata, Ivet M.] Univ Pelita Harapan, Mochtar Riady Inst Nanotechnol, Tangerang, Banten, Indonesia; [Zhou, Hong-Hao] Cent S Univ, Inst Clin Pharmacol, Hunan Sheng, Peoples R China; [Tan, Sheng-Lan] Cent S Univ, Xiangya Hosp 2, Dept Pharm, Hunan Sheng, Peoples R China; [Tatarunas, Vacis; Lesauskaite, Vaiva] Lithuanian Univ Hlth Sci, Inst Cardiol, Lab Mol Cardiol, Kaunas, Lithuania; [Zhang, Yumao; Maitland-van der Zee, Anke H.; de Boer, Anthonius] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands; [Maitland-van der Zee, Anke H.] Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands; [Verhoef, Talitha, I] UCL, Dept Appl Hlth Res, London, England; [Taljaard, Monica] Univ Ottawa, Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada; [Taljaard, Monica] Univ Ottawa, Ottawa Hosp Res Inst, Dept Epidemiol & Community Med, Ottawa, ON, Canada; [Zambon, Carlo Federico] Univ Padua, Dept Med DIMED, Padua, Italy; [Pengo, Vittorio] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy; [Zhang, Jieying Eunice; Pirmohamed, Munir] Univ Liverpool, Dept Mol & Clin Pharmacol, Wolfson Ctr Personalised Med, Liverpool, Merseyside, England
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, Green Accepted
- 발행기관 WILEY
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160006
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/cpt.1323
- PubMed https://pubmed.ncbi.nlm.nih.gov/30506689
초록/요약
The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at the individual patients level to capture the possible effect of ethnicity, gene-gene interaction, or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. The final collection consists of 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95% confidence interval (CI) 7-10%), with a higher effect in women, in patients taking acenocoumarol, and in white patients. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived.
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