Clinical and Biomarker Characteristics According to Clinical Spectrum of Alzheimer's Disease (AD) in the Validation Cohort of Korean Brain Aging Study for the Early Diagnosis and Prediction of AD
- 주제(키워드) Alzheimer's disease , mild cognitive impairment , biomarkers , cohort study , subjective cognitive decline
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Hwang, Jihye] Keimyung Univ, Dept Neurol, Dongsan Med Ctr, Daegu 41931, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Dept Neurol, Sch Med, Seoul 07985, South Korea; [Yoon, Soo Jin] Eulji Univ, Sch Med, Dept Neurol, Daejeon 35233, South Korea; [Park, Kyung Won] Dong A Univ, Coll Med, Dong A Med Ctr, Dept Neurol, Busan 49201, South Korea; [Kim, Eun-Joo] Pusan Natl Univ, Sch Med, Pusan Natl Univ Hosp, Dept Neurol, Busan 49241, South Korea; [Kim, Eun-Joo] Med Res Inst, Busan 49241, South Korea; [Yoon, Bora] Konyang Univ, Dept Neurol, Coll Med, Daejeon 35365, South Korea; [Jang, Jae-Won] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Coll Med, Dept Neurol, Chunchon 24289, South Korea; [Kim, Hee Jin] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul 06351, South Korea; [Hong, Jin Yong] Yonsei Univ, Wonju Coll Med, Dept Neurol, Wonju 26426, South Korea; [Lee, Jong-Min; Choi, Yong-Ho; Park, Gilsoon; Hong, Jinwoo] Hanyang Univ, Dept Biomed Engn, Seoul 04763, South Korea; [Park, Hyuntae] Dong A Univ, Dept Hlth Care & Sci, Busan 49315, South Korea; [Kang, Ju-Hee] Inha Univ, Sch Med, Dept Pharmacol, Incheon 22212, South Korea; [Byun, Min Soo; Yi, Dahyun] Seoul Natl Univ, Med Res Ctr, Inst Human Behav Med, Seoul 03080, South Korea; [Kim, Yu Kyeong] SMG SNU Boramae Med Ctr, Dept Nucl Med, Seoul 07061, South Korea; [Lee, Dong Young] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul 03080, South Korea; [Lee, Dong Young] Dept Seoul Natl Univ Coll Med, Seoul 03080, South Korea; [Choi, Seong Hye] Inha Univ, Sch Med, Dept Neurol, Incheon 22332, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, gold, Green Published
- 발행기관 MDPI
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160015
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm8030341
- PubMed https://pubmed.ncbi.nlm.nih.gov/30862124
초록/요약
We aimed to present the study design of an independent validation cohort from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (AD) (KBASE-V) and to investigate the baseline characteristics of the participants according to the AD clinical spectrum. We recruited 71 cognitively normal (CN) participants, 96 with subjective cognitive decline (SCD), 72 with mild cognitive impairment (MCI), and 56 with AD dementia (ADD). The participants are followed for three years. The Consortium to Establish a Registry for AD scores was significantly different between all of the groups. The logical memory delayed recall scores were significantly different between all groups, except between the MCI and ADD groups. The Mini-Mental State Examination score, hippocampal volume, and cerebrospinal fluid (CSF) amyloid-beta 42 level were significant difference among the SCD, MCI, and ADD groups. The frequencies of participants with amyloid pathology according to PET or CSF studies were 8.9%, 25.6%, 48.3%, and 90.0% in the CN, SCD, MCI, and ADD groups, respectively. According to ATN classification, A+/T+/N+ or A+/T+/N- was observed in 0%, 15.5%, 31.0%, and 78.3% in the CN, SCD, MCI, and ADD groups, respectively. The KBASE-V showed a clear difference according to the AD clinical spectrum in neuropsychological tests and AD biomarkers.
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