Blood amyloid- oligomerization associated with neurodegeneration of Alzheimer's disease
- 주제(키워드) Oligomerization , Blood-based biomarker , Amyloid , Oligomer , Multimer detection system , Voxel-based morphometry , Multimer detection system-oligomeric A
- 주제(기타) Clinical Neurology; Neurosciences
- 설명문(일반) [Youn, Young Chul] Chung Ang Univ, Dept Neurol, Coll Med, Seoul, South Korea; [Kang, Sungmin] PeopleBio Inc, Res & Dev, Gyeonggi Do, South Korea; [Suh, Jeewon; Park, Young Ho; Kang, Min Ju; Kim, SangYun] Seoul Natl Univ, Bundang Hosp, Dept Neurol, Coll Med, Gyeonggi Do, South Korea; [Kang, Min Ju; Pyun, Jung-Min] Vet Hlth Serv Med Ctr, Dept Neurol, Seoul, South Korea; [Choi, Seong Hye] Inha Univ, Dept Neurol, Sch Med, Incheon, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Dept Neurol, Mokdong Hosp, Seoul, South Korea; [Park, Kyung Won] Dong A Univ, Dept Neurol, Coll Med, Busan, South Korea; [Park, Kyung Won] Inst Convergence Biohlth, Busan, South Korea; [Lee, Ho-Won] Kyungpook Natl Univ, Dept Neurol, Sch Med, Daegu, South Korea; [An, Seong Soo A.] Gachon Univ, Dept Bionanotechnol, Incheon, South Korea; [Dominguez, Jacqueline C.] St Lukes Med Ctr, Inst Neurosci, Quezon City, Philippines
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 BMC
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160017
- 본문언어 영어
- Published As http://dx.doi.org/10.1186/s13195-019-0499-7
- PubMed https://pubmed.ncbi.nlm.nih.gov/31077246
초록/요약
IntroductionOligomeric amyloid-ss is a major toxic species associated with Alzheimer's disease pathogenesis. Methods used to measure oligomeric amyloid- in the blood have increased in number in recent years. The Multimer Detection System-Oligomeric Amyloid- (MDS-OA) is a specific method to measure oligomerization tendencies in the blood. The objective of this study was to determine the association between amyloid-ss oligomerization in the plasma and structural changes of the brain.MethodsWe studied 162 subjects composed of 92 community-based normal healthy subjects, 17 with subjective cognitive decline, 14 with mild cognitive impairment and 39 with Alzheimer's disease dementia. All subjects underwent MDS-OA and three-dimensional T1 magnetic resonance imaging. To determine the structural changes of the brain that are statistically correlated with MDS-OA level, we used voxel-based morphometry with corrections for age and total intracranial volume covariates.ResultsWe found brain volume reduction in the bilateral temporal, amygdala, parahippocampal and lower parietal lobe and left cingulate and precuneus regions (family-wise error, p<0.05). Reduction was also found in white matter in proximity to the left temporal and bilateral lower parietal lobes and posterior corpus callosum (family-wise error, p<0.05). Brain volume increment was not observed in any regions within grey or white matter.DiscussionFindings suggest that substantial correlation exists between amyloid ss oligomerization in the blood and brain volume reduction in the form of Alzheimer's disease despite of uncertainty in the casual relationship.
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