Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment
- 주제(키워드) mild cognitive impairment , cognitive training , brain PET
- 주제(기타) Geriatrics & Gerontology
- 설명문(일반) [Park, Jinse; Kim, Si-Eun; Lee, Byung In] Inje Univ, Haueundae Paik Hosp, Dept Neurol, Busan, South Korea; [Kim, Eun-Joo] Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Neurol, Sch Med, Busan, South Korea; [Kim, Eun-Joo] Med Res Inst, Busan, South Korea; [Jeong, Jee Hyang] Ewha Womans Univ, Sch Med, Dept Neurol, Mokdong Hosp, Seoul, South Korea; [Na, Hae Ri] Bobath Mem Hosp, Dept Neurol, Seongnam, South Korea; [Choi, Seong Hye] Inha Univ, Dept Neurol, Sch Med, Incheon, South Korea; [Kang, Do-Young] Dong A Univ, Dept Nucl Med, Coll Med, Busan, South Korea; [Park, Kyung Won] Dong A Univ, Dept Neurol, Cognit Disorders & Dementia Ctr, Coll Med, Busan, South Korea; [Park, Kyung Won] Inst Convergence Biohlth, Busan, South Korea
- 등재 SCIE, SCOPUS
- OA유형 Green Submitted, gold, Green Published
- 발행기관 DOVE MEDICAL PRESS LTD
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160018
- 본문언어 영어
- Published As http://dx.doi.org/10.2147/CIA.S200269
- PubMed https://pubmed.ncbi.nlm.nih.gov/31303750
초록/요약
Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.
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