Recent therapeutic trends and promising targets in triple negative breast cancer
- 주제(키워드) Clinical trials , Experimental targets , Metastatic triple negative breast cancer (mTNBC) , Preclinical implication , Small molecules , Targeted therapy
- 등재 SCIE, SCOPUS
- OA유형 hybrid
- 발행기관 Elsevier Inc.
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160023
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.pharmthera.2019.02.006
- PubMed https://pubmed.ncbi.nlm.nih.gov/30825473
초록/요약
Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast cancer (TNBC) comprises around 15~20% of breast cancers. Conventional chemotherapy and radiation are the primary systemic therapeutic strategies; no other FDA-approved targeted therapies are yet available as for TNBC. TNBC is generally characterized by a poor prognosis and high rates of proliferation and metastases. Due to these aggressive features and lack of targeted therapies, numerous attempts have been made to discover viable molecular targets for TNBC. Massive cohort studies, clinical trials, and in-depth analyses have revealed diverse molecular alterations in TNBC; however, controversy exists as to whether many of these changes are beneficial or detrimental in caner progression. Here we review the complicated tumorigenic processes and discuss critical findings and therapeutic trends in TNBC with a focus on promising therapeutic approaches, the clinical trials currently underway, and potent experimental compounds under preclinical and evaluation. © 2019 The Authors
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