Plasma membrane redox enzymes: new therapeutic targets for neurodegenerative diseases
- 주제(키워드) Mitochondrial dysfunction , Neurodegenerative diseases , Oxidative stress , Plasma membrane redox enzymes
- 주제(기타) Chemistry, Medicinal; Pharmacology & Pharmacy
- 설명문(일반) [Hyun, Dong-Hoon] Ewha Womans Univ, Dept Life Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- 발행기관 PHARMACEUTICAL SOC KOREA
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160081
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-019-01147-8
- PubMed https://pubmed.ncbi.nlm.nih.gov/30919268
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Mitochondrial dysfunction caused by oxidative stress appears at early stages of aging and age-related diseases. Plasma membrane redox enzymes act in a compensatory manner to decrease oxidative stress and supply reductive capacity to ensure cell survival. Plasma membrane redox enzymes transfer electrons from NAD(P)H to oxidized ubiquinone and -tocopherol, resulting in inhibition of further oxidative damage. Plasma membrane redox enzymes and their partners are affected by aging, leading to progression of neurodegenerative disease pathogenesis. Up-regulating plasma membrane redox enzymes via calorie restriction and phytochemicals make cells more resistant to oxidative damage under stress conditions by maintaining redox homeostasis and improving mitochondrial function. Investigation into plasma membrane redox enzymes can provide mechanistic details underlying the relationships between plasma membrane redox enzymes and mitochondrial complexes and provide a good therapeutic target for prevention and delay of neurodegenerative disorders.
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