In silico construction of a flexibility-based DNA Brownian ratchet for directional nanoparticle delivery
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Park, Suehyun; Song, Jeongeun; Kim, Jun Soo] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; [Park, Suehyun] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
- 등재 SCIE, SCOPUS
- OA유형 Green Published, gold
- 발행기관 AMER ASSOC ADVANCEMENT SCIENCE
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160220
- 본문언어 영어
- Published As http://dx.doi.org/10.1126/sciadv.aav4943
- PubMed https://pubmed.ncbi.nlm.nih.gov/30972363
초록/요약
Brownian particles confined in a system with periodic and asymmetric potential can be transported in a specific direction along the potential by repetitively switching the potential on and off. Here, we propose a DNA-based Brownian ratchet for directional transport of positively charged nanoparticles in which nanoparticle delivery follows the path dictated by a single, long, double-stranded DNA. We performed Brownian dynamics simulations to prove its realization using coarse-grained models. A periodic and asymmetric potential for nanoparticle binding is constructed along a single, long, double-stranded DNA molecule by a novel strategy that uses variation in sequence-dependent DNA flexibility. Directional and processive motion of nanoparticles is achieved by changing salt concentration repetitively over several cycles to switch the asymmetric potential on and off. This work suggests that double-stranded DNA molecules with elaborately designed flexibility variation can be used as a molecule-scale guide for spatial and dynamic control of nanoparticles for future applications.
more