Brain Microglial Activation in Chronic Pain-Associated Affective Disorder
- 주제(키워드) brain microglia , microglial activation , chronic pain , depression , TNF-alpha
- 주제(기타) Neurosciences
- 설명문(일반) [Barcelon, Ellane Eda; Choi, Woo-Hyun; Lee, Sung Joong] Seoul Natl Univ, Sch Dent, Dept Neurosci & Physiol, Seoul, South Korea; [Barcelon, Ellane Eda; Choi, Woo-Hyun; Lee, Sung Joong] Seoul Natl Univ, Sch Dent, Dent Res Inst, Seoul, South Korea; [Jun, Sang Beom] Ewha Womans Univ, Dept Brain & Cognit Sci, Seoul, South Korea
- 등재 SCIE
- OA유형 gold, Green Published
- 발행기관 FRONTIERS MEDIA SA
- 발행년도 2019
- URI http://www.dcollection.net/handler/ewha/000000160225
- 본문언어 영어
- Published As http://dx.doi.org/10.3389/fnins.2019.00213
- PubMed https://pubmed.ncbi.nlm.nih.gov/30949019
초록/요약
A growing body of evidence from both clinical and animal studies indicates that chronic neuropathic pain is associated with comorbid affective disorders. Spinal cord microglial activation is involved in nerve injury-induced pain hypersensitivity characterizing neuropathic pain. However, there is a lack of thorough assessments of microglial activation in the brain after nerve injury. In the present study, we characterized microglial activation in brain sub-regions of CX3CR1(GFP/+) mice after chronic constriction injury (CCI) of the sciatic nerve, including observations at delayed time points when affective brain dysfunctions such as depressive-like behaviors typically develop. Mice manifested chronic mechanical hypersensitivity immediately after CCI and developed depressive-like behaviors 8 weeks post-injury. Concurrently, significant increases of soma size and microglial cell number were observed in the medial prefrontal cortex (mPFC), hippocampus, and amygdala 8 weeks post-injury. Transcripts of CD11b, and TNF-alpha, genes associated with microglial activation or depressive-like behaviors, are correspondingly upregulated in these brain areas. Our results demonstrate that microglia are activated in specific brain sub-regions after CCI at delayed time points and imply that brain microglial activation plays a role in chronic pain-associated affective disorders.
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